Biography
Holly Brown-Borg is a UND Chester Fritz Distinguished Professor of Biomedical Sciences at the UND School of Medicine & Health Sciences. She has a broad understanding of the aging field, with specific expertise in the areas of endocrinology, stress resistance, and metabolism. She was the first to discover that growth hormone (GH) deficiency significantly extended lifespan in mice and has worked to understand the mechanisms underlying healthspan and longevity. Her laboratory has shown that the unique physiology attributed to reduced GH signaling in mice leads to delayed aging and resistance to age-related diseases. Recent translational projects are directed at understanding susceptibility and resistance to disease, specifically hepatosteatosis and neurodegeneration, as well as understanding factors that contribute to sarcopenia and frailty. She is the Chair of the NIH National Institute on Aging Board of Scientific Counselors, reviews regularly for multiple NIH panels, and serves on multiple journal editorial boards. She has chaired/organized many aging meetings, including the Biology of Aging Gordon Research Conference, Keystone Conference on Aging, FASEB Scientific Research Conference, and Chairs the International Symposium on Neurobiology & Neuroendocrinology of Aging in Austria (2010-2026). She serves on the Board of the American Aging Association and completed terms on the FASEB (Federation of American Societies for Experimental Biology) and the Gerontological Society of America boards. She is a Fellow of the American Aging Association, the Gerontological Society of America, and the American Association for the Advancement of Science. She was recently elected to the Academy for Health and Lifespan Research.
JOURNAL ARTICLES
Sturmlechner I, Ashiqueali SA, Martini H, Valdivieso K, Franco AC, Guthikonda P, Dosch AJ, Prieto LL, Asmussen NC, Latham AC, Redden JT, Leitschuh EA, Mashek DG, Passos JF, Rodriguez-Lopez J, Monroe TB, Bernlohr DA, Robbins PD, Knopf BA, Lamming DW, Johnston MJ, Brown-Borg HM, Tye S, Rhoads TW, Gate DM, Childs BG, Baker DJ, Li X, Miller RA, Jang IH, Camell CD, Miller Z, Phatnani H, KonopkAR, PhD, Haak AJ, Vanegas-Avendano N, Akula RN, Limkar AR, Ricke WA, Leiser SF, Correia J, Bai H, Olszewski S, Seldeen KL, Budinger GRS, MD, Morales-Nebreda LC, Winter DR, PhD, McCrady-Spitzer SK, Anderson RM, Mihaylova MM, Rojas M, Mora AL, LeBrasseur NK, Schafer MJ. 2025 The Sixth Annual Symposium of the Midwest Aging Consortium. Journals of Gerontology: Biological Sciences. doi: 10.1093/gerona/glaf280.
Johnston MJ, Brown-Borg HM. 2025. Utilizing accelerated and delayed murine models of aging to address the ’healthspan issue’: A review of skeletal muscle health. Aging Research Reviews doi.org/10.1016/j.arr.2025.102946
Osan JK, Rakoczy SG, Pecoraro HL, Brown-Borg HM. 2025. Longevity-driven hepatic transcriptional programs mediate resilience to diet-induced liver injury in Ames dwarf mice. Geroscience. doi: 10.1007/s11357-025-02017-6.
Johnston MJ, Rakoczy SG, Thompson LV, Brown-Borg HM. 2025. Growth hormone-deficient Ames dwarf mice resist sarcopenia and exhibit enhanced endurance running performance at 24 months. Geroscience doi.org/10. 1007/ s11357- 025- 01630-9.
Shi X, Fu N, Zhang H, Brown-Borg HM, Wang S, Zhao RC. 2025. Bioengineering strategies for augmenting wound-healing efficacy of mesenchymal stem cell-derived extracellular vesicles. Sci Bull (Beijing) 70(7):987-990. doi: 10.1016/j.scib.2024.10.024.PMID: 39505664
Wang Z, Gao P, Guo, K, Schirrick G, Singh Gill, J, Weis J, Lund Da Costa A, Rahman, M Mehta H, Fleecs J,Jain S, Debnath T, Jur J, Khan N, Sticca R, Brown-Borg H, Jurivich DA, Mathur R. 2024. Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer. JCI Insight 9(5):e167676. doi: 10.1172/jci.insight.167676.
Villeda S, Brown-Borg H, Anderson R. 2023. Neurobiology of aging: New insights from across the research spectrum. J Gerontology Biological Sciences Jun 1;78(6):869-871. doi: 10.1093/gerona/glad110.
Kai G, Wang Z, Debnath T, Mehta H, Abrham E, Even Z, Rahman M, Lund Da Costa A, Jain S, Wang X, Hur J, Gopal M, Ting A, Brown-Borg HM, Jurivich DA, Khan N, Mathur R. 2022. Mitochondrial transcription factor A regulates Foxp3+ T cell mediated maintenance of CD4+ T cell landscapes and immunological aging. bioRxiv 2022.03.08.483517; doi: https://doi.org/10.1101/2022.03.08.483517
Trivedi R, Knopf B, Rakoczy S, Manocha GD, Brown-Borg H, Jurivich DA. 2023. Disrupted HSF1 regulation in normal and exceptional brain aging. Biogerontology Sept 14. doi: 10.1007/s10522-023-10063-w.
Perazza LR, Gower AC, Brown-Borg HM, Divieti P, Thompson LV. 2023. Protectin DX as a therapeutic strategy against frailty in mice. Geroscience doi: 10.10007/s11357-023-00789-3. PMID: 37059838
Han J, Wang J, Shi H, Li Q, Zhang S, Wu H, Li W, Zhuang C, Gan L, Chen Y, Feng W, Brown-Borg HM, Zhao RC. 2023. Ultrasmall polydopamine Nanomedicine-enabled antioxidation against senescence. Materials Today Bio 19:100544. doi: 10.1016/j.mtbio.2023.10054. PMID: 3674780
Noureddine S, Saccon T, Rudeski-Rohr;T, Gesing A, Mason JB, Schneider A, Dhabhi J, Puig KL, Rakoczy S, Brown-Borg HM, Masternak MM. 2022. GH-deficiency confers protective advantages against Alzheimer’s disease through rescued miRNA expression profile in APP/PS1 mice. Geroscience 44(6):2885-2893. doi: 10.1007/s11357-022-00633-0. PubMed PMID: 35900661.
Brown-Borg HM. 2022. Growth hormone, not IGF-1 is the key longevity regulator in mammals. J Gerontol A Biol Sci Med Sci. Apr 18:glac092. doi: 10.1093/gerona/glac092
Perazza L, Brown-Borg HM, Thompson LV. 2022. Physiological systems promoting frailty. Comprehensive Physiology. (in press).
Bartke A, Brown-Borg H. 2021. Mutations affecting mammalian aging: GH and GHR vs IGF-1 and insulin. Front Genet. 2021 Nov 24;12:667355. doi: 10.3389/fgene.2021.667355
Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg HM, Jurivich D. 2021. Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice. Geroscience 43(4):1921-1934. doi: 10.1007/s11357-021-00362-w.
Zhu R, Yan, T, Feng Y, Liu Y, Cao H, Peng G, Yang Y, Xu Z, Liu J, Hou W, Wang X, Li Z, Deng L, Wang S, Li J, Han Q, Li H, Shan G, Cao Y, An X, Yan J, Zhang Z, Li H, Qu X, Zhu J, Zhou S, Wang J, Zhang F, Gao J, Jin R, Xu D, Ma Y, Huang T, Peng S, Zheng Z, Stambler I, Gilson E, Lim LW, Moskalev A, Cano A, Chakrabarti S, Ulfhake B, Su H, Xu H, Xu S, Wei F, Brown-Borg HM, Min K-J, Ellison-Hughes G, Caruso C, Jin K, Zhao RC. 2021. Mesenchymal stem cell treatment improves outcomes in COVID-19 patients via multiple immunomodulatory mechanisms. Cell Research-Nature 26:1-19. doi: 10.1038/s41422-021-00573-y.
Nacarelli T, Azar A, Potnis M, Johannes G, Mell J, Bene M, Johnson FB, Brown-Borg H, Nogouchi E, Sell C. 2022. The methyltransferase enzymes, KMT2D, SETD1B, and ASH1L, are key mediators of both metabolic and epigenetic changes during cellular senescence. Molecular Biology of the Cell May 1;33(5):ar36. doi: 10.1091/mbc.E20-08-0523.
Pabis K, Chiari Y, Sala C, Straka E, Giacconi R, Provinciali M, Brown-Borg H, Nowikovsky K, Valencak T, Gundacker C, Garagnani P, Malavolta M. 2021. Elevated metallothionein in long-lived species mediates the influence of cadmium accumulation on aging. Geroscience 43(4):1975-1993. doi:10.1007/s11357-021-00393-3.
Tomkinson GR, Kidokoro T, Dufner T, Noi S, Fitzgerald JS, Brown-Borg HM. 2021. Temporal trends in the 6-minute walking distance of older Japanese adults between 1998 and 2017. Journal of Sport and Health Science 10(4):462-469. doi: 10.1016/j.jshs.2020.06.007.
Thelen, M, Brown-Borg, HM. 2020. Does diet have a role in the treatment of Alzheimer’s disease? Frontiers in Aging Neuroscience. 12:617071. doi: 10.3389/fnagi.2020.627071.
Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg HM, Jurivich D. 2021. Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice. Geroscience doi: 10.1007/s11357-021-00362-w.
Brown-Borg HM. 2020. ‘A glance back’ at the Journals of Gerontology: We’ve come a long way, baby! J Gerontol A Biol Sci Med Sci 75(2):205-206.
Brown-Borg HM, Borg KE. 2020. A summary of the Proceedings of the Fourteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 15-20, 2018. Geroscience 42(5):1195-1198. doi: 10.1007/s11357-020-00234-9.
Tomkinson GR, Kidokoro T, Dufner T, Noi S, Fitzgerald JS, Brown-Borg HM. 2020. Temporal trends in the 6-minute walking distance of older Japanese adults between 1998 and 2017. Journal of Sport and Health Science S2095-2546(20)30073-9. doi: 10.1016/j.jshs.2020.06.007.
Buffenstein R, Lewis KN, Gibney PA, Grimes K, Narayan V, Smith M, Lin T, Brown-Borg HM. 2020. Probing paedomorphy and prolonged lifespan in the naked mole-rats and dwarf mice. Physiology 35(2): 96-111. doi.org/10.1152/physiol.00032.2019
Jurivich D, Manocha G, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H. 2020. Multi-factorial attenuation of the murine heat shock response with age. J Gerontol A Biol Sci doi: 10.1093/gerona/glz204.
Royce GH, Brown-Borg HM, Deepa SS. 2019. The potential role of necroptosis in inflammaging and aging. Geroscience 41(6):795-811. Doi:10.1007/s11357-019-00131-w.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Borg KE, Rojanathammanee L. 2018. Metabolic adaptation of short-living growth hormone transgenic mice to methionine restriction and supplementation. Annals of the New York Academy Sciences 1418(1):118-136.
Brown-Borg HM. Disentangling high fat, low carb and healthy aging. 2017. Cell Metabolism 26(3):458-459.
Brown-Borg HM, Anderson RM. 2017. Metabolic adventures in aging research. Molecular and Cellular Endocrinology 455 (1-3).
Cole JJ, Robertson NA, Rather MI, McBryan T, Brock C, Clark W, Miller RA, Brown-Borg H*, Adams PD*. 2017. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions. Genome Biology 18(1):58. *Corresponding authors
Wang T, Tsui B, Kreisberg JF, Robertson NA, Gross AM, Carter H, Brown-Borg H, Adams PD, Ideker T. 2017. Epigenetic aging signatures in mice is slowed by dwarfism, caloric restriction and Rapamycin treatment. Genome Biology 18(1):57.
Brown-Borg HM, Borg KE. 2017. A summary of the Proceedings of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17-22, 2016. Experimental Gerontology 94:1-128..
Brown-Borg HM, Buffenstein R. 2016. Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan? Ageing Research Reviews pii: S1568-1637(16)30204-5. doi: 10.1016/j.arr.2016.08.007.
Puig KL, Kulas JA, Franklin W, Rakoczy SG, Taglialatela G, Brown-Borg HM, Combs CK. 2016. The Ames dwarf mutation attenuates Alzheimer’s disease phenotype of APP/PS1 mice. Neurobiology of Aging 40:22-40. doi: 10.1016/j.neurobiolaging.2015.12.021.
Brown-Borg HM. 2015. Reduced GH signaling and methionine restriction: Interventions that improve metabolic health and lifespan. Annals of the New York Academy of Sciences. 1363(1):40-49.
Brown-Borg HM. 2015. The somatotropic axis and longevity in mice. Am J Physiology Endo Metab. 309(6):E503-510. doi:10.1152/ajpendo.00262.2015.
Brown-Borg, HM, Borg KE. 2015. A summary of the proceedings of the Twelfth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 27-August 1, 2014. Experimental Gerontology doi:10.1016/j.exger.2015.01.004.
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y,Vijg J, Vinciguerra M, Fontana L. 2015. Interventions to slow aging in humans: Are we ready? Aging Cell 14(4):497-510. doi: 10.1111/acel.12338
Brown-Borg HM, S Rakoczy, JA Wonderlich, V Armstrong, L. Rojanathammanee. 2014. Altered dietary methionine differentially impacts glutathione and methionine metabolism in long living growth hormone deficient Ames dwarf and wild type mice. Longevity and Healthspan 3:10. doi:10.1186/2046-2395-3-10.
Brown-Borg, H.M., S. Rakoczy, J.A. Wonderlich, L. Rojanathammanee, J.J. Kopchick, V. Armstrong and D. Raasakka. 2014 Growth hormone signaling is necessary for lifespan extension by dietary methionine. Aging Cell 13(6):1019-1027. doi: 10.1111/acel.12269.
Rojanathammanee, L., S. Rakoczy, J.J. Kopchick and H.M. Brown-Borg. 2014. Effects of insulin-like growth factor 1 on glutathione S-transferases and thioredoxin in growth hormone receptor knockout mice. AGE 36(4):9687-9693. doi: 10.1007/s11357-014-9687-3
Ables, G.P., H.M. Brown-Borg, R. Buffenstein, C.D. Church, A.K. Elshorbagy, V.D. Gladyshev, T. Huang, R.A. Miller, J.R. Mitchell, J.P. Richie, B. Rogina, M.H. Stipanuk, D.S. Orentreich, and N. Orentreich, 2014. The first international mini-symposium on methionine-restriction and lifespan. Frontiers in Genetics: Genetics of Aging 5:122. 09 May/doi: 10.3389/fgene.2014.00122.
Derenne, A., H.M. Brown-Borg, S. Martner, W. Wolff, M. Frerking. 2014. Spatial delayed nonmatching-to-sample performances in long-living Ames dwarf mice. Physiology and Behavior 123:100-104. PMID 24140989
Rojanathammanee, L., S. Rakoczy and H.M. Brown-Borg. 2014. Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 69(10):1199-1211. doi: 10.1093/gerona/glt178
Armstrong, V.L., S. Rakoczy, L. Rojanathamannee, H.M. Brown-Borg. 2014. Expression of DNA methyltransferases are influenced by growth hormone in the long living Ames dwarf mouse. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 69(8): 923-933. doi:10.1093/gerona/glt133
Romanick, M.A., L.V. Thompson and H.M. Brown-Borg. 2013. Murine models of atrophy, cachexia and sarcopenia in skeletal muscle. Biochimica et Biophysica Acta. 1832:1410-1420. doi:10.1016/j.bbadis.2013.03.011
Brown-Borg, H.M. and K.E. Borg. 2013. A summary of the proceedings of the Eleventh International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 29-August 3, 2012. Experimental Gerontology 48(7):593-595.
Brown-Borg, H.M., and S. Rakoczy. 2013. Metabolic adaptations to short-term every other day feeding in long-living Ames dwarf mice. Experimental Gerontology 48:905-919. doi.org/10.1016/j.exger.2013.06.009
Brown-Borg, H.M. and A. Bartke. 2012. GH and IGF1: Roles in energy metabolism of long-living GH mutant mice. J. Gerontology Series A: Biological Sciences and Medical Sciences 67(6):652-660 doi: 10.1093/Gerona/gls086. PMC3348496
Anisimov, V.N., Bartke, A., Barzilai, N., Batin, M.A., Blagosklonny, M.V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., Franceschi, C., Gems, D., Gladyshev, V., Gorbunova, V., Gudkov, A.V., Kennedy, B., Konovalenko, M., Kraemer, B., Moskalev, A., Petropoulos, I., Pasyukova, E., Rattan, S., Rogina, B., Seluanov, A., Shaposhnikov, M., Shmookler Reis, R., Tavernarakis, N., Vijg, J., Yashin, A., Zimniak, P. 2012. The second international conference on ‘genetics of aging and longevity’. Aging 4(5):305-317.
Traustadottir, T., S.S. Davies, Y. Su, L, Choi, H.M. Brown-Borg, L.J. Roberts, II, and S.M. Harman. 2012. Oxidative stress in older adults: Effects of physical fitness. AGE 34:969-982. doi:10.1007/s11357-011-9277-6.
Brown-Borg, H.M., W.T. Johnson and S. Rakoczy. 2012. Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice. AGE 34(1):43-57. doi:10.1007/s11357-011-9212-x. PMID 3260352
Morrissey, M.B., H.M. Brown-Borg, R. de Cabo and M. Silverstein. 2011. An interdisciplinary look at advancing pain care, education and research: Responding to the IOM’s call to action to improve pain management. From Publication to Practice – The Gerontological Society of America pp. 1-4.
Sharma, S., D. Darland, S. Lei, S. Rakoczy and H.M. Brown-Borg. 2011. NMDA and kainate receptor expression, long-term potentiation and neurogenesis in long-lived Ames dwarf mice. AGE 34(3):609-620 doi:10.1007/s11357-011-9253-1. PMC3337943
Brown-Borg, H.M. and K.E. Borg. 2011. A summary of the proceedings of the Tenth International Symposium on Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 25-30, 2010. Experimental Gerontology Vol. 46 Issues 2-3. PMC3159923
Derenne, A., H.M. Brown-Borg, K. Feltman, G. Corbett and S. Lackman. 2011. Acquisition of steady-state operant behavior in long-living Ames dwarf mice. Physiology and Behavior 104(5):1048-1052. doi:10.1016/j.physbeh.2011.07.006
Sharma, S., J. Haselton, S.G. Rakoczy, S. Branshaw, and H.M. Brown-Borg. 2010. Spatial memory is enhanced in long-living Ames dwarf mice and maintained following kainic acid induced neuronal loss. Mechanisms of Ageing & Development 131(6):422-435 doi:10.1016/j.mad.2010.06.004
Sharma, S., S.G. Rakoczy and H.M. Brown-Borg. 2010. Assessment of spatial memory in mice. Life Sciences 87(17-18):521-536. doi:10.1016/j.lfs.2010.09.004
Sharma, S., S.G. Rakoczy, K. Dahlheimer and H.M. Brown-Borg. 2010. The hippocampus of Ames dwarf mice is resistant to kainic acid-induced oxidative stress. Experimental Gerontology 45:936-949.
Vallanat, B., S.P. Anderson, H.M. Brown-Borg, H. Ren, S. Jonnalagadda, R. Srinivasan and J.C. Corton. 2010. Analysis of the heat shock response in the mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor a (PPARa). BMC Genomics 11:16-24. PMC2823686
Ren, H., Vallanat, B., H.M. Brown-Borg, R. Currie, and J.C. Corton. 2010. Regulation of proteome maintenance gene expression by activators of peroxisome proliferator-activated receptor a. PPAR Research 2010; 2010:727194. doi10.1155/2010/727194 PMC3026993
Chen, C-n, H.M. Brown-Borg, S. Rakoczy, D. Ferrington, L.V. Thompson. 2010. Aging impairs the expression of glutamate cysteine ligase catalytic subunit in soleus muscle under stress. J. Gerontology: Biological Sciences 65(2):129-137. doi: 10.1093/gerona/glp194. PMC2806238
Brown-Borg, H.M. 2009. Hormonal control of aging in rodents: The somatotropic axis. Molecular and Cellular Endocrinology 299(1):64-71.
Brown-Borg, H.M., S. G. Rakoczy, S. Sharma and A. Bartke. 2009. Long-living growth hormone receptor knock out mice: potential mechanisms of altered stress resistance. Experimental Gerontology 44:10-19. PMC2743895
Dhanasekaran, M., S.S. Karuppagounder, S. Uthayathas, L. Wold, K. Parameshwaran, J. Babu, V. Suppiramaniam and H. Brown-Borg. 2008. Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content. Life Sciences 83:92-95.
Chen, C.-n., H.M. Brown-Borg, S.G. Rakoczy, L.V. Thompson. 2008. Muscle disuse: adaptation of antioxidant systems is age-dependent. J Gerontology: Biological Sciences 63A(5):461-466. PMC2670877
Shavali, S., H.M. Brown-Borg, M. Ebadi and J. Porter. 2008. Mitochondrial localization of alpha-synuclein protein in alpha-synuclein-overexpressing cells. Neuroscience Letters 439(2):125-128. PMC2502066
Dhanasekaran, M., C.B. Albano, L. Pellet, S.S. Karuppagounder, S. Uthayathas, V. Suppiramaniam, H.M. Brown-Borg, M. Ebadi. 2008. Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced toxicity. Neurochemical Research 33(6):980-984 .
S
- Research Associate, Physiology, Southern Illinois University
- Research Associate, Endocrinology, USDA ARS MARC
- Ph.D., Physiology, North Carolina State University
- M.S., Animal Science, University of Nebraska-Lincoln
- B.S., University of Nebraska-Lincoln
Determining pathways and mechanisms that hormones utilize may suggest potential therapeutic interventions that could lead to strategies to delay aging, treat aging-related disorders, and extend health and life span in humans.
The somatotropic axis plays a major role in aging processes and longevity. Mice with hereditary dwarfism (Ames dwarf, df/df) and growth hormone deficiency exhibit delayed aging, living 49-68% longer (males and females, respectively) than their wildtype siblings. We have discovered multiple physiological differences that contribute to the extension of healthspan in this long-living mouse, including enhanced antioxidative capacity, mitochondrial function, stress resistance, and mechanisms that promote methylation, resulting in youthful DNA methylation patterns. Characteristics of skeletal muscle health are improved in dwarf mice and correspond with maintenance of youthful function well into old age. These mice also exhibit resistance to dietary insults such as high-fat diets by avoiding symptoms of metabolic syndrome (insulin resistance, fatty liver, inflammation).
The overall hypothesis is that reduced somatotropic signaling confers a biologic advantage (increased healthspan and delayed aging) to mammals with metabolic reprogramming for better enzymatic scavenging of toxic metabolic byproducts, less mitochondrial leakage (improved efficiency), and enhanced stress resistance.
Our current studies are designed to investigate the relationships between metabolism, hormones, and aging in mouse strains of extended and shortened lifespan. Translationally, these studies will contribute information to better understand sarcopenia, frailty, fatty liver disease, and other metabolic disorders, as well as neurodegenerative diseases.
Awards/Honors
Stanford-Elsevier Top 2% Scientists list 2025
Student Support Award, UND Biomedical Sciences Graduate Student Association May 2025
Elected Member of the Academy of Health & Lifespan Research 2024
NIH NIA Board of Scientific Counselors 2021-2026; Chair 2024-2026
2021 Endocrine Society New Frontiers in Basic Science Conference Moderator & Panel Discussant 2021
Appointed Assistant Dean for Gender Equity UND SMHS 2021-
UND SMHS Outstanding Unified Session III Instructor Award 2020-21
Elected Fellow of American Association for the Advancement of Science for distinguished contributions to the biology of aging 2018
UND 2018 Fellows of the University Award for Departmental Excellence in Research
UND SMHS Block 3 Instructor Award 2014, 2017, 2018, 2019, 2020
Keynote address-NIH National Institute on Aging-Division of Aging Biology New Investigators Forum 2016
Fellow of the American Aging Association 2016
Co-Organizer 2018 Keystone Symposium ‘Pushing the Limits to Healthspan and Longevity’
2015 Aging Cell journal Runner-Up Best Paper Prize for 2014
Distinguished Research Award; Eurosymposium on Healthy Ageing, Belgium 2014
American Aging Association Lifetime Achievement Denham Harman Research Award 2013
UND Foundation Thomas J. Clifford Faculty Achievement Award for Excellence in Research 2013
Glenn Award for Research in Biological Mechanisms of Aging 2011
Alpha Omega Alpha Medical Society – elected to faculty membership 2011
UND North Dakota Spirit Faculty Achievement Award 2011
UND Chester Fritz Distinguished Professor 2010
UND North Dakota Spirit Faculty Achievement Award 2010
UND Fellows of the University Award for Departmental Excellence in Research 2010
President - American Aging Association 2010-2011
Chair - Biological Sciences section of Gerontological Society of America 2010-2011
Chair International Symposium Neurobiology & Neuroendocrinology of Aging Austria 2009-present
Glenn Award for Research in Biological Mechanisms of Aging 2008
Chair-Gordon Research Conference on Biology of Aging (Switzerland) September 2007
UND Dean H. David Wilson Academic Award in Neurosciences 2007
Fellow of the Gerontological Society of America 2006